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Diagnosis and Nutritional Treatment of Genome and Epigenome
Damage on an Individual Basis
By  PhD, CSIRO
It is becoming increasingly evident that (a) risk for developmental and degenerative disease increases with more DNA damage, which in turn is dependent on nutritional status, and (b) the optimal concentration of micronutrients for prevention of genome damage is also dependent on genetic polymorphisms that alter the function of genes involved directly or indirectly in the uptake and metabolism of micronutrients required for DNA repair and DNA replication.
The development of dietary patterns, functional foods and supplements that are designed to improve genome-health maintenance in individuals with specific genetic backgrounds may provide an important contribution to an optimum health strategy based on the diagnosis and individualised nutritional prevention of genome damage, i.e. genome health clinics.
Lectures will cover a range of developmental and degenerative disease including Alzheimers, Autism and Cancer to dimensionalise how seemingly unrelated diseases share key underlying issues. Focus will be on nutritional genomics approaches to preventing neurodevelopmental disorders by identifying those pregnancies, neonates and children at risk and then implementing optimal nutrition designed for specific genetic sub-groups to prevent DNA damage.
Doctor Fenech will also review 1) efficient biomarkers for diagnosing genome and/or epigenome instability 2) genotoxins 3) micronutrients required as cofactors or as components of DNA repair enzymes and prevention of DNA oxidation 4) the concept of recommended dietary allowances for genome stability 5) how diet impacts on genome stability and 6) how genotype determines nutritional requirements for genome health maintenance.
Michael Fenech
Adjunct Professor, University of South Australia
CSIRO Food and Nutritional Sciences
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Professor Michael Fenech is renowned internationally for his research in nutrition and genetic toxicology and for developing the cytokinesis-block micronucleus (CBMN) assay which is a gold standard method used internationally to measure DNA damage in human cells. His key goal is to determine the nutritional requirements for DNA damage prevention. In 2003-05, Dr Fenech proposed a novel disease prevention strategy based on personalised diagnosis and prevention of DNA damage by appropriate diet/life-style intervention, which has led to the Genome Health Clinic concept which has been translated into practice (www.reach100.com.au). In 2000-2006 his laboratory further developed the CBMN assay into a 'cytome' assay consisting of six complementary biomarkers of DNA damage and cytotoxicity and in 2009 developed an improved method to measure absolute telomere length, a molecular biomarker of accelerated ageing. He was awarded the Flinders University’s Convocation Medal in 2007, the Alexander Hollaender Award (USA) in 2008 and the honorary title of Adjunct Professor (University of South Australia) in 2009 for his leadership/contributions to environmental/public health sciences internationally. His publications have been cited 6,500 times (917 times in 2008, 890 times in 2009) and his H-index is 41.
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