Summary:
Acetaminophen (paracetamol) is commonly used in pregnancy, but research suggests prenatal exposure may increase the risk of Autism Spectrum Disorder (ASD) and ADHD symptoms in children. This study investigated the link between acetaminophen and these conditions, looking at data from nearly 74,000 mother-child pairs across six European cohorts. Acetaminophen exposure was assessed during pregnancy and up to 18 months postnatally through maternal interviews. Children’s ASD and ADHD symptoms were evaluated between ages 4 and 12. The results showed that prenatal acetaminophen use was linked to a 19% higher risk of ASD symptoms and a 21% higher risk of ADHD symptoms, with slightly stronger effects in boys. Postnatal exposure showed no association with symptoms or these conditions. These findings highlight the importance of informing pregnant women about potential risks associated with acetaminophen use during pregnancy.
Abstract:
Acetaminophen (paracetamol) is commonly used in pregnancy, but research suggests prenatal exposure may increase the risk of Autism Spectrum Disorder (ASD) and ADHD symptoms in children. This study investigated the link between acetaminophen and these conditions, looking at data from nearly 74,000 mother-child pairs across six European cohorts. Acetaminophen exposure was assessed during pregnancy and up to 18 months postnatally through maternal interviews. Children’s ASD and ADHD symptoms were evaluated between ages 4 and 12. The results showed that prenatal acetaminophen use was linked to a 19% higher risk of ASD symptoms and a 21% higher risk of ADHD symptoms, with slightly stronger effects in boys. Postnatal exposure showed no association with symptoms or these conditions. These findings highlight the importance of informing pregnant women about potential risks associated with acetaminophen use during pregnancy.
Article Publication Date: 28/05/2021
DOI: 10.1007/s10654-021-00754-4
