Research Papers

The Impact of Diet, Probiotics, Prebiotics and Antibiotics on Atopic Dermatitis


Atopic dermatitis (AD) is a common immune-mediated condition which is largely misunderstood. Atopic dermatitis is extremely common and has almost tripled in prevalence over the last 30 years in western countries, particularly in children. Currently, 30% of children and roughly 10% of adults are impacted by AD. There are a variety of possible causes of AD such as diet, stress, or physical contact with substances such as preservatives and antimicrobial agents. The current pharmacological treatment includes topical steroids which has many side effects. Therefore, other methods to reduce the symptoms of AD are in dire need. This paper is a review of the current evidence on AD and diet, including soy, polyphenols, minerals and vitamins and their ability to regulate inflammation. The results show that an anti-inflammatory diet containing a wide range of vitamins and minerals can be helpful and that probiotics and prebiotics can positively modulate the gut microbiota by alleviating inflammation which is implicated in AD. The researchers also reviewed studies that showed that children who were born to mothers with AD and used antibiotics during pregnancy had an increased likelihood of AD.

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Allergic contact dermatitis is one of the most common recorded occupational diseases. There are many different substances that the skin comes into contact with on a daily basis and that can cause ACD, e.g., preservatives, surfactants, and antimicrobial agents. The development of a mouse model of ACD has provided insight into the immune mechanisms involved. Drugs used in the treatment of skin diseases have many side effects. Therefore, alternative methods of suppressing the immune response to reduce the symptoms of skin diseases are being sought. In recent years, high hopes have been placed on dietary modulation and supplementation to affect the intestinal microbial composition and promote anti-inflammatory responses. In addition, other studies have shown the crucial role of intestinal microbiota in many immune-mediated diseases. Recognition and characterization of pro- and anti-inflammatory nutrients and supplements may be crucial to support the treatment of diseases such as atopic dermatitis, acne vulgaris, psoriasis, and allergic contact dermatitis.

Article Publication Date: 2/2/2023
DOI: 10.1007/s43440-023-00454-8

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