Summary:
Sarcopenia, characterized by muscle decline, is associated with adverse health outcomes and exhibits varying prevalence rates across age groups. Risk factors include physical inactivity, malnutrition, smoking, sleep disturbances, and diabetes. Emerging evidence suggests a potential link between gut microbiota and sarcopenia, necessitating further investigation into the preventive and therapeutic effects of dietary microbes. It is well-documented that dietary microbes may positively impact immune regulation and gut function, potentially reducing susceptibility to chronic diseases. While research has explored the associations of dietary live microbes with health outcomes, their relationship with sarcopenia remains unexplored. This study aimed to assess this relationship using national survey data from 2011 to 2018. Data from 5,368 participants were collected via a self-reported dietary questionnaire, and participants were classified into low, medium, and high dietary live microbe groups. After adjusting for potential confounders, individuals in the high dietary live microbe group had a lower sarcopenia prevalence compared to those in the low dietary live microbe group, suggesting that increased dietary live microbe intake was linked to a reduced risk of sarcopenia.
Abstract:
Objective: This study aimed to investigate the potential association between dietary live microbe intake and sarcopenia.
Methods: Data from 5,368 participants were gathered from the National Health and Nutrition Examination Survey (NHANES). Dietary information was assessed using a self-report questionnaire. The participants were categorized into low, medium, and high dietary live microbe groups. Sarcopenia was defined according to the National Institutes of Health (NIH) definition (appendicular skeletal muscle mass/body mass index < 0.789 for men and < 0.512 for women). Multivariate regression analysis and stratified analyses were performed.
Results: After adjusting for potential confounding factors, individuals in the high dietary live microbe group exhibited a lower prevalence of sarcopenia compared to those in the low dietary live microbe group. The adjusted odds ratio (with 95% confidence intervals) was 0.63 (0.44∼0.89) (p for trend <0.05). Subgroup analyses indicated a potential difference in the impact of dietary live microbe intake on sarcopenia between individuals with and without diabetes (p for interaction=0.094). Conclusion: Higher dietary live microbe intake was associated with a lower risk of sarcopenia.
Article Publication Date: 22/05/2024
DOI: 10.1016/j.clnu.2024.05.030
