Summary:
The objective of this randomized-controlled trial was to analyse the impact of fenugreek seed extract on various aspects of health in adult patients with Alzheimer’s disease (AD), including memory, depression, quality of life, blood pressure and oxidative stress markers. The study involved 82 AD patients experiencing mild-to-moderate memory impairment. Participants in the intervention group received 5ml of fenugreek seed extract daily for 4 months, while those in the control group were administered a placebo. Baseline assessments of memory, depression, quality of life, blood pressure and other health markers were conducted both before and after the intervention period. Results revealed significant improvements in the fenugreek group in memory and quality of life, as well as reductions in depression, systolic blood pressure and diastolic blood pressure and oxidative stress markers, compared to baseline. These findings indicate promising benefits of fenugreek seed extract supplementation for memory, quality of life, blood pressure, and certain oxidative markers in AD patients.
Abstract:
The aim of the current randomized control trial (RCT) study was to investigate the effects of fenugreek seed extract on memory, depression, quality of life, blood pressure, and serum malondialdehyde (MDA) and total antioxidant capacity (TAC) levels in adult AD patients. This randomized clinical trial was conducted in geriatric homes in Iran. The study participants included 82 AD patients with mild-to-moderate memory deficit. Patients in the intervention group received 5 cc of fenugreek seed extract for 4 months and subjects in the control group received a placebo. Memory, depression, quality of life, and BP levels, as well as serum MDA and TAC, were assessed before and after the intervention. There was a significant increase in serum levels of TAC (p < 0.001) and a reduction in serum MDA status (p < 0.001) after 4 months of fenugreek seed extract supplementation. In addition, increasing levels of memory (p < 0.001) and quality of life (p < 0.001), as well as reduction of depression (p = 0.002), systolic BP (p < 0.001), and diastolic BP (p < 0.001) levels were detected in the intervention group compared with baseline. Fenugreek seed extract supplementation in AD patients shows promising positive effects on memory, quality of life, BP, and selective oxidative indices levels.
Article Publication Date: 05/10/2022
DOI: 10.1002/ptr.7612
