Integrative Healthcare for the Whole Family

Research

Categories

ADHD Allergies Autism Biomedicine
Digestive Health Nutrition Mental Health Metabolic
Immunologic Neurologic Developmental Celiac
Health and Old Age Heart Disease  Depression

Highly Recommended

ARI References (dozens of biomedical studies) 
ARI References 2008
Parent Ratings of Behavorial Effects of Biomedical Interventions

ADHD
ADHD and Food Additives Revisited 2008;19;17, DOL:10:1542/gr.19-2-17Apraxia-Dyspraxia-Dyslexia, Jul/Aug 2009, VOL. 15, NO. 4The Guardian, UK Edition,Allegra Stratton Ritalin of no long-term benefit, Monday 12 November 2007Amiri, S. et al. (2012). Pregnancy-Related Maternal Risk Factors of Attention-Deficit Hyperactivity Disorder: A Case-Control Study. ISRN Pediatrics.Schwarz, A. (2013). A.D.H.D. Seen in 11% of U.S. Children as Diagnoses Rise. New York Times.

Amiri, S. et al. (2012). Pregnancy-Related Maternal Risk Factors of Attention-Deficit Hyperactivity Disorder: A Case-Control Study. ISRN Pediatrics.

Autism
A.W. Zimmerman,An Expanding Spectrum of Autism ModelsMartha R. Herbert and Matthew P. AndersonFrom Fixed Developmental Defects to Reversible Functional Impairment, Chapter 20 , 2008, 429 -463CoMed Inc, Press Release,Landmark Study Finds Mercury Poisoning Causes Autism, October 10, 2008Autism Advocate, Fifth Edition, Martha R. Herbert, M.D., Ph.D,Time to Get a Grip, 2008, 19 -25Los Angeles Times, Chris Woolston,Robots used to help autistic children, October 17, 2011 Autism Research Centre, Department of Psychiatry, Cambridge University, Cambridge, UK, Ruta L, Ingudomnukul E, Taylor K, Chakrabarti B, Baron-Cohen S,Increased serum androstenedione in adults with autism spectrum conditions, 2011Epidemiology Journal, Schmidt, RJ, RL Hansen, J Hartiala, H Allayee, LC Schmidt, DC Tracredi, F Tassone and I Hertz-Picciott,Prenatal vitamins lower autism risk, 2011CHARGE Study, Volk HE, Hertz-Picciotto I, Delwiche L, Lurmann F,Residential proximity to freeways and autism in the CHARGE studyStudy to investigate DNA damage and autism

Gastrointestinal problems common in children with autism. Science Daily.

American Academy of Pediatrics. Gastrointestinal problems common in children with autism. Science Daily.

S.J Blumberg (2013). Changes in Prevalence of parent-reported Autism Spectrum Disorder in school-aged U.S. Children: 2007 to 2011–2012. National Health Statistics Report No. 65.

Genuis, S. J. (2013). Celiac Disease Presenting as Autism/ Journal of Childhood Neurology. 25 (1).

Reichelt, K. L. & Knivsberg, A. M. (2003). Can the Pathophysiology of Autism be Explained by the Nature of the Discovered Urine Peptides? Nutritional Neuroscience. 6 (1).

Whiteley, P. et al. (1999). A Gluten Free-Diet as an Intervention for Autism and Associated Spectrum Disorders: Preliminary Findings. Autism. 3 (1).

Pennesi, C. M. & Klein, L. C. (2012). Effectiveness of the gluten-free, casein-free diet for children diagnosed with autism spectrum disorder: Based on parental report. Nutritional Neuroscience. 15 (2).

Celiac

O’Brien, K. (2011). Should We All Go Gluten-Free? New York Times.Chase, C (2011).Is Novak Djokovic’s new, gluten-free diet behind his win streak? Yahoo! SportsBasic definition of gluten and its effect on the body. Health Spring Holistic.Perlmutter, D. (2010). Gluten Sensitivity and the Impact on the Brain. Huffington PostHadjivassiliou, M (1996). Does Cryptic Gluten Sensitivity Play a part in Neurological Illness. Lancet 347 (8988).Ford, Rodney, (2009). The Gluten Syndrome: A Neurological Disease. Medical Hypotheses 73 (3).Dr Vojdani’s work and publications. Your Medical Detective.H. William (2006). Cognitive Impairment and Celiac Disease. Archives of Neurology.Bernadette Kalman and Thomas H. Brannagan III. Chapter 22. Neurological Manifestations of Gluten Sensitivity. Neuroimmunology in Clinical Practice. (Wiley-Blackwell 2007).

Hadjivassiliou, M (2002). Gluten Sensitivity as a Neurological Illness. Science Direct.Hallert, C. & Astrom, J. (1982). Psychic Disturbances in Adult Coeliac Disease. Scandinavian Journal of Gastroenterology. 17 (1).Ludvigsson, J. F. et al. (2007). Coeliac disease and risk of mood disorders — A general population-based cohort study. Journal of Affective Disorders. 99 (1-3).Ludvigsson, J. F. et al. (2011). Increased Suicide Risk in Coeliac disease— A Swedish nationwide cohort study. Digest of Liver Disorders. 43 (8).Carta, M. G. (2003). Recurrent brief depression in celiac disease. Journal of Psychosomatic Research. 55 (6).

Briani, C. et al. (2008). Neurological complications of celiac disease and autoimmune mechanisms: A prospective study. Journal of Neuroimmunology. 195 (1-2).

Rattue, G. (2012). Schizophrenia Risk In Kids Associated With Mothers’ Gluten Antibodies. Medical News Today.

Dimitrrova, A. K. et al. (2013). Prevalence of Migraine in Patients With Celiac Disease and Inflammatory Bowel Disease. Headache. 53 (2).

Lionetti, E, et al. (2009). Headache in Pediatric Patients With Celiac Disease and Its Prevalence as a Diagnostic Clue. Journal of Pediatric Gastroenterology & Nutrition. 49 (2).

Corvagalia, L. et al. (1999). Depression in adult untreated celiac subjects: diagnosis by the pediatrician. American Journal of Gastroenterology. 94 (3).

Greenblatt, J. M. (2011) Is Gluten Making You Depressed? The Link between Celiac Disease and Depression. Psychology Today.

Verkasalo, M. A. (2005). Undiagnosed silent coeliac disease: A risk for underachievement? Scandinavian Journal of Gastroenterology. 40 (12).

Akobeng, A. K. et al. (2006). Effect of breast feeding on risk of coeliac disease: a systematic review and meta-analysis of observational studies. Archives of Disease in Childhood. 91 (1).Genuis, S. J. (2013). Celiac Disease Presenting as Autism/ Journal of Childhood Neurology. 25 (1).

Biomedicine

40 Studies on Biomedicine Biomedical Intervention in AutismBiomedical ResearchDietary Triggers of Abdominal Symptomsin Patients With Irritable Bowel SyndromeInfection Chronic Neuro Diseases Nicolson Lab Medicine 2008McGinnes On Mauve Factor London Oct 2006Mitochondrial DisorderMitochondrial gene expression in the human gastrointestinal tract Nutritional Therapies For Mental Health DisordersVitamin B6Prenatal vitamins lower autism riskFisetin Lowers Methylglyoxal Dependent Protein Glycation and Limits the Complications of Diabetes

 Depression

Fournier, J. C. et al. (2010). Antidepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis. JAMA 303 (1).

Shin, J. Y. et al. (2008). Are Cholesterol and Depression Inversely Related? A Meta-analysis of the Association Between Two Cardiac Risk Factors. Annals of Behavioural Medicine. 36(1).

Study: Statins cause memory loss, depression

J. Greenblatt (2011). Low Cholesterol and Its Psychological Effects: Low Cholesterol is Linked to Depression, Suicide, and Violence

Morgan, R. E. (1993). Plasma cholesterol and depressive symptoms in older men. Lancet. 341 (8837).

Digestive Health

Digestion & Poor HealthNormal gut microbiota modulates brain development and behavior.Neurologic and Psychiatric Manifestations of Celiac Disease and Gluten SensitivityIngestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.Scientific American: The Neuroscience of the GutMitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysisAir pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphologySludge Sloughs Off Perfluorinated ChemicalsPerfluorochemicals May Postpone PubertyAntibiotics can permanently destroy gut flora balance, leading to lifelong illness Mercury levels in maternal and cord blood and attained weight through the 24 months of life Overuse of Antibiotics increases the risk of obesity Antibiotics can permanently destroy gut flora balance, leading to lifelong illness

Health and Old Age

Harlan M. Krumholz (1994). Lack of Association Between Cholesterol and Coronary Heart Disease Mortality and Morbidity and All-Cause Mortality in Persons Older Than 70 Years. JAMA 272.International Journal of Epidemiology. 41 (3).Hollander, E. L. et al (2012). The association between waist circumference and risk of mortality considering body mass index in 65- to 74-year-olds: a meta-analysis of 29 cohorts involving more than 58 000 elderly persons. International Journal of Epidemiology. 41 (3).

Harman, D. (1956). Aging: A Theory Based on Free Radical and Radiation Chemistry. Journal of Gerontology. 11 (3).

Harman, D. (1972). Free Radical Theory of Aging: Dietary Implications. American Journal of Clinical Nutrition. 25 (8).

Murray, C. J. L. & Lopez, A. D. (1996). Global Burden of Disease: A comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020. World Health Organization.Morgan, R. E. (1993). Plasma cholesterol and depressive symptoms in older men. Lancet. 341 (8837).

Nutrition

Organic Food Literature ReviewThe Rainbow of Food DyesIt’s Not an Apple a Day After All — It’s StrawberriesNutritional supplements and their effect on glucose control.Relative Intake of Macronutrients Impacts Risk of Mild Cognitive Impairment or DementiaZioudrou, C (1979). Opioid peptides derived from food proteins. The exorphins. Journal of Biological Chemistry. 254 (7).Petousis-Harris H. (2011). Saturated Fat has been unfairly demonised: Yes. Primary Health Care 3 (4).Newport, M (2008). WHAT IF THERE WAS A CURE FOR ALZHEIMER’S DISEASE AND NO ONE KNEW?Vanitalli, T. B. et al. Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study. Neurology. 64 (4).Stafstrom, C. E. & Rho, J. M. (2012). The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders. Frontiers in Pharmacology.Araya, A. V. et al. (2008). Evaluation of the effect of caloric restriction on serum BDNF in overweight and obese subjects: preliminary evidences. Endocrine. 33 (3).Cara B. Ebbeling. (2012). Effects of Dietary Composition on Energy Expenditure During Weight-Loss MaintenanceMarcus, A.D. (2012). Mad-Cow Disease May Hold Clues To Other Neurological Disorders. Wall Street Journal.Taubes, G. (2010). Why We Get Fat: And What To Do About ItLustig, R. H. Sugar: The Bitter TruthTaubes, G. (2011) Is Sugar Toxic? NY TimesGood calories, Bad calories: Challenging the Conventional Wisdom on Diet, Weight Control and Disease.Lustig, R. H. (2012). Public Health: The Toxic Truth about Sugar

Gandhi, S & Abramov, A. (2012). Mechanism of Oxidative Stress in Neurodegeneration.

Seneff, Stephanie (2009). APOE-4: The Clue to Why Low Fat Diet and Statins may Cause Alzheimer’s

Siri-Tarino,P. (2010). Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. American Journal of Clinical Nutrition.

Ziegler, D. R. (2003) Ketogenic Diet Increases Glutathione Peroxidase Activity in Rat Hippocampus. Neurochemical Research. 28 (12).

Siwek, M. et al. (2009). Zinc supplementation augments efficacy of imipramine in treatment resistant patients: A double blind, placebo-controlled study. Journal of Affective Disorders. 118 (1-3).

Kraft, B. D. & Westman, E. C. (2009). Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature. Nutrition and Metabolism. 6 (10).

Perlmutter, David. Power Up Your Brain: The Neuroscience of Enlightenment (2011)

Boettler, U. (2011). Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression. Journal of Nutritional Biochemistry. 22 (5).Corvagalia, L. et al. (1999). Depression in adult untreated celiac subjects: diagnosis by the pediatrician. American Journal of Gastroenterology.

Heart Disease

Siri-Tarino,P. (2010). Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. American Journal of Clinical Nutrition.Ramón Estruch. (2013) Primary Prevention of Cardiovascular Disease with a Mediterranean DietMelton, S. T. (2013). Are Cholesterol Levels Linked to Bipolar Disorder? Medscape Today News.

Mental Health

The Viral Link to Mental IllnessNew Study Shows This Vitamin Helps Prevent DepressionDSM5 in Distress Relative Intake of Macronutrients Impacts Risk of Mild Cognitive Impairment or DementiaIs Alzheimer’s Type 3 Diabetes?Jose Miguel Rubio-Perez and Juana Maria Morillas-Ruiz (2012). A Review: Inflammatory Process in Alzheimer’s Disease, Role of Cytokines.The Scientific World Journal.Mulder, M. (1998). Reduced Levels of Cholesterol, Phospholipids, and Fatty Acids in Cerebrospinal Fluid of Alzheimer Disease Patients Are Not Related to Apolipoprotein E4.Alzheimer Disease and Associated Disorders.P. Barberger-Gateau (2007). Dietary patterns and risk of dementia: The Three-City cohort study.Neurology. 69 (20).Centre For Advancing Health. Statins do not help prevent Alzheimers Disease.Seneff, Stephanie (2009). APOE-4: The Clue to Why Low Fat Diet and Statins may Cause Alzheimer’sLonneke M. L. de Lau (2008). Serum Cholesterol Levels and the Risk of Parkinson’s Disease. American Journal of Epidemiology. 164 (10).Duane Graveline. Lipitor, Thief of MemoryJ. Lee (2004) Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms.Srivastava, S. et al. (2011). Role of Sirtuins and Calorie Restriction in Neuroprotection: Implications in Alzheimer’s and Parkinson’s Diseases. Current Pharmaceutical Design.Newport,M (2008). WHAT IF THERE WAS A CURE FOR ALZHEIMER’S DISEASE AND NO ONE KNEW?Van der Auwera, I. et al. (2008). A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer’s disease. Nutrition and Metabolism. 2 (28).

Yurko-Mauro, K. et al. (2010) Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimer’s and Dementia. 6 (6).

Morris, M. C. (2003). Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease. Archives of Neurology. 60 (7).

Schaefer, E. J. et al (2006). Plasma Phosphatidylcholine Docosahexaenoic Acid Content and Risk of Dementia and Alzheimer Disease: The Framingham Heart Study. Archives of Neurology. 63 (11).Corvagalia, L. et al. (1999). Depression in adult untreated celiac subjects: diagnosis by the pediatrician. American Journal of Gastroenterology. 94 (3).

Lowe, T. L. (1982). Stimulant Medications Precipitate Tourette’s Syndrome. JAMA. 247 (12).

Metabolic

Culver A. L., et al. (2012). Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women’s Health Initiative. Arch Intern Med. 172(2):144-152.Zhang, Q, et al. (2009). A Perspective on the Maillard Reaction and the Analysis of Protein Glycation by Mass Spectrometry: Probing the Pathogenesis of Chronic Disease


Immunologic

Questions Persist: Environmental Factors in Autoimmune Disease.

Neurologic

Marcus, A.D. Mad-Cow Disease May Hold Clues To Other Neurological Disorders. Wall Street Journal.  (2012)Newport, M (2008). WHAT IF THERE WAS A CURE FOR ALZHEIMER’S DISEASE AND NO ONE KNEW?Reger, M. A. et al. (2004). Effects of β-hydroxybutyrate on cognition in memory-impaired adults. Neurobiology of Ageing. 25 (3).Gasior, M. et al. (2006). Neuroprotective and disease-modifying effects of the ketogenic diet. Behavioural Pharamacology. 17 (5-6).Nakajo, Y. et al. (2008). Genetic increase in brain-derived neurotrophic factor levels enhances learning and memory. Brain Research.Molteni, R. et al. (2002). A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience. 112 (4).Stafstrom, C. E. & Rho, J. M. (2012). The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders. Frontiers in Pharmacology.Mattson, M. P. et al. (2004) Prophylactic Activation of Neuroprotective Stress Response Pathways by Dietary and Behavioral Manipulations. NeuroRx.Norman Doidge.(2012) The brain that changes itself: Stories of personal triumph from the frontier of brain sciencesPeter S. Eriksson. (1998) Neurogenesis in the adult h The brain that changes itself: Stories of personal triumph from the frontier of brain sciencesuman hippocampus David Perlmutter. (2011) Power up your brain: the neuroscience enlightenmentRaji, C. A. et al (2010). Brain Structure and Obesity. Human Brain Mapping. 31 (3).Geroldi, C. et al. (2005) Insulin Resistance in Cognitive Impairment: The InCHIANTI Study. Achives of Neurology.

Baranano, K. W. et al. (2008). The ketogenic diet: Uses in epilepsy and other neurologic illnesses. Current Treatment Options in Neorology. 10 (6).

Xiong, G. L & Doraiswamy, P. M. (2009) Does Meditation Enhance Cognition and Brain Plasticity? Annals of the NY Academy of Sciences 1172.

Markesbery, W. R. & Lovell, M. A. (2007). Damage to Lipids, Proteins, DNA, RNA in Mild Cognitive Impairment. Archives of Neurology. 64 (7).

Gao, L. et al. (2007). Novel n-3 Fatty Acid Oxidation Products Activate Nrf2 by Destabilizing the Association between Keap1 and Cullin3. Journal of Biological Chemistry. 282 (4).

Zelnik, N. et al. (2004). Range of Neurologic Disorders in Patients With Celiac Disease. Pediatrics. 113 (6).

Developmental

A cloud over our lives: Air pollution linked to learning problems and depressionAir Pollution Stunts CognitionPrenatal Exposure to Phthalates and Infant Development at Six Months: Prospective Mothers and Children’s Environmental HealthChildren less attentive, more impulsive with higher exposure to repellent chemicalsCommon Drugs Linked to Cognitive Impairment and Possibly to Increased Risk of Death, Study SuggestsFrom the Fields to Inner City, Pesticides Affect Children’s IQPollutants’ Passage From Mother To ChildToxins found in pregnant U.S. women in UCSF studyQuestions Persist: Environmental Factors in Autoimmune DiseaseÃ…sa Blomström, Maternal Antibodies to Dietary Antigens and Risk for Nonaffective Psychosis in Offspring

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